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The structure of an RNAi polymerase links RNA silencing and transcription.

Abstract:

RNA silencing refers to a group of RNA-induced gene-silencing mechanisms that developed early in the eukaryotic lineage, probably for defence against pathogens and regulation of gene expression. In plants, protozoa, fungi, and nematodes, but apparently not insects and vertebrates, it involves a cell-encoded RNA-dependent RNA polymerase (cRdRP) that produces double-stranded RNA triggers from aberrant single-stranded RNA. We report the 2.3-A resolution crystal structure of QDE-1, a cRdRP from N...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
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Journal:
PLoS biology
Volume:
4
Issue:
12
Publication date:
2006-12-01
DOI:
EISSN:
1545-7885
Source identifiers:
94470
Language:
English
Pubs id:
pubs:94470
UUID:
uuid:7c07affe-1b81-49ba-89ec-1256f5640acf
Local pid:
pubs:94470
Deposit date:
2012-12-19

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