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The structure of an RNAi polymerase links RNA silencing and transcription.

Abstract:

RNA silencing refers to a group of RNA-induced gene-silencing mechanisms that developed early in the eukaryotic lineage, probably for defence against pathogens and regulation of gene expression. In plants, protozoa, fungi, and nematodes, but apparently not insects and vertebrates, it involves a cell-encoded RNA-dependent RNA polymerase (cRdRP) that produces double-stranded RNA triggers from aberrant single-stranded RNA. We report the 2.3-A resolution crystal structure of QDE-1, a cRdRP from N...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
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Journal:
PLoS biology
Volume:
4
Issue:
12
Publication date:
2006-12-05
DOI:
EISSN:
1545-7885
URN:
uuid:7c07affe-1b81-49ba-89ec-1256f5640acf
Source identifiers:
94470
Local pid:
pubs:94470
Language:
English

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