Journal article
Antiviral activity of bone morphogenetic proteins and activins
- Abstract:
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Understanding the control of viral infections is of broad importance. Chronic hepatitis C virus (HCV) infection causes decreased expression of the iron hormone hepcidin, which is regulated by hepatic bone morphogenetic protein (BMP)/SMAD signalling. We found that HCV infection and the BMP/SMAD pathway are mutually antagonistic. HCV blunted induction of hepcidin expression by BMP6, probably via tumour necrosis factor (TNF)-mediated downregulation of the BMP co-receptor haemojuvelin. In HCV-inf...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
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(pdf, 11.1MB)
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(pdf, 2.2MB)
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(pdf, 315.0KB)
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- Publisher copy:
- 10.1038/s41564-018-0301-9
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Authors
Funding
Oxford Martin School
More from this funder
+ National Institutes of Health
More from this funder
Grant:
NIAID U19AI082630
NIDDK R01DK087727
RO1DK-069533
O1DK-071837
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Microbiology Journal website
- Volume:
- 4
- Pages:
- 339–351
- Publication date:
- 2018-12-03
- Acceptance date:
- 2018-10-22
- DOI:
- ISSN:
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2058-5276
- Pubs id:
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pubs:951384
- URN:
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uri:7c05c5b1-da07-4449-973f-eb6e7a57ebdc
- UUID:
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uuid:7c05c5b1-da07-4449-973f-eb6e7a57ebdc
- Local pid:
- pubs:951384
Item Description
- Language:
- English
Terms of use
- Copyright holder:
- Eddowes et al.
- Copyright date:
- 2018
- Notes:
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This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/s41564-018-0301-9
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