- Abstract:
-
Understanding the control of viral infections is of broad importance. Chronic hepatitis C virus (HCV) infection causes decreased expression of the iron hormone hepcidin, which is regulated by hepatic bone morphogenetic protein (BMP)/SMAD signalling. We found that HCV infection and the BMP/SMAD pathway are mutually antagonistic. HCV blunted induction of hepcidin expression by BMP6, probably via tumour necrosis factor (TNF)-mediated downregulation of the BMP co-receptor haemojuvelin. In HCV-inf...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 11.1mb)
-
(pdf, 2.2mb)
-
(pdf, 315.0kb)
-
- Publisher copy:
- 10.1038/s41564-018-0301-9
-
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- Grant:
- NIAID U19AI082630
- NIDDK R01DK087727
- RO1DK-069533
- O1DK-071837
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Microbiology Journal website
- Volume:
- 4
- Pages:
- 339–351
- Publication date:
- 2018-12-03
- Acceptance date:
- 2018-10-22
- DOI:
- ISSN:
-
2058-5276
- Pubs id:
-
pubs:951384
- URN:
-
uri:7c05c5b1-da07-4449-973f-eb6e7a57ebdc
- UUID:
-
uuid:7c05c5b1-da07-4449-973f-eb6e7a57ebdc
- Local pid:
- pubs:951384
- Language:
- English
- Copyright holder:
- Eddowes et al.
- Copyright date:
- 2018
- Notes:
-
This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/s41564-018-0301-9
Journal article
Antiviral activity of bone morphogenetic proteins and activins
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