Journal article icon

Journal article

Antiviral activity of bone morphogenetic proteins and activins

Abstract:

Understanding the control of viral infections is of broad importance. Chronic hepatitis C virus (HCV) infection causes decreased expression of the iron hormone hepcidin, which is regulated by hepatic bone morphogenetic protein (BMP)/SMAD signalling. We found that HCV infection and the BMP/SMAD pathway are mutually antagonistic. HCV blunted induction of hepcidin expression by BMP6, probably via tumour necrosis factor (TNF)-mediated downregulation of the BMP co-receptor haemojuvelin. In HCV-inf...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41564-018-0301-9

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0002-3297-2483
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Expand authors...
Oxford Martin School More from this funder
Expand funders...
Publisher:
Springer Nature Publisher's website
Journal:
Nature Microbiology Journal website
Volume:
4
Pages:
339–351
Publication date:
2018-12-03
Acceptance date:
2018-10-22
DOI:
ISSN:
2058-5276
Pmid:
30510168
Source identifiers:
951384
Language:
English
Pubs id:
pubs:951384
UUID:
uuid:7c05c5b1-da07-4449-973f-eb6e7a57ebdc
Local pid:
pubs:951384
Deposit date:
2018-12-31

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP