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Antiviral activity of bone morphogenetic proteins and activins

Abstract:

Understanding the control of viral infections is of broad importance. Chronic hepatitis C virus (HCV) infection causes decreased expression of the iron hormone hepcidin, which is regulated by hepatic bone morphogenetic protein (BMP)/SMAD signalling. We found that HCV infection and the BMP/SMAD pathway are mutually antagonistic. HCV blunted induction of hepcidin expression by BMP6, probably via tumour necrosis factor (TNF)-mediated downregulation of the BMP co-receptor haemojuvelin. In HCV-inf...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41564-018-0301-9

Authors


Eddowes, LA More by this author
Al-Hourani, K More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
ORCID:
0000-0002-3297-2483
Frankish, J More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Weatherall Insti. of Molecular Medicine
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Grant:
109965/Z/15/Z
WT091663MA
Oxford Martin School More from this funder
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Grant:
NIAID U19AI082630
NIDDK R01DK087727
RO1DK-069533
O1DK-071837
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Microbiology Journal website
Volume:
4
Pages:
339–351
Publication date:
2018-12-03
Acceptance date:
2018-10-22
DOI:
ISSN:
2058-5276
Pubs id:
pubs:951384
URN:
uri:7c05c5b1-da07-4449-973f-eb6e7a57ebdc
UUID:
uuid:7c05c5b1-da07-4449-973f-eb6e7a57ebdc
Local pid:
pubs:951384
Language:
English

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