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Journal article

Sequence changes in predicted promoter elements of STK11/LKB1 are unlikely to contribute to Peutz-Jeghers syndrome.

Abstract:

BACKGROUND: Germline mutations or large-scale deletions in the coding region and splice sites of STK11/LKB1 do not account for all cases of Peutz-Jeghers syndrome (PJS). It is conceivable that, on the basis of data from other diseases, inherited variation in promoter elements of STK11/LKB1 may cause PJS. RESULTS: Phylogenetic foot printing and transcription factor binding site prediction of sequence 5' to the coding sequence of STK11/LKB1 was performed to identify non-coding sequences of DNA...

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Publication status:
Published
Peer review status:
Peer Reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1471-2164-6-38

Authors


Hearle, NC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Swarbrick, E More by this author
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Publisher:
BioMed Central Ltd. Publisher's website
Journal:
BMC genomics Journal website
Volume:
6
Pages:
Article no. 38
Publication date:
2005
DOI:
EISSN:
1471-2164
ISSN:
1471-2164
URN:
uuid:7be9a52c-1f26-4df3-87f1-264f1cf14ee2
Source identifiers:
72041
Local pid:
pubs:72041

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