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Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.

Abstract:

Inducible nitric oxide synthase (iNOS) is a key enzyme in the macrophage inflammatory response, which is the source of nitric oxide (NO) that is potently induced in response to proinflammatory stimuli. However, the specific role of NO production, as distinct from iNOS induction, in macrophage inflammatory responses remains unproven. We have generated a novel mouse model with conditional deletion of Gch1, encoding GTP cyclohydrolase 1 (GTPCH), an essential enzyme in the biosynthesis of tetrahy...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Wellcome Trust Centre for Human Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine
Role:
Author
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Oxford NIHR Biomedical Research Centre More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Free radical biology and medicine Journal website
Volume:
79
Pages:
206-216
Publication date:
2015-02-05
DOI:
EISSN:
1873-4596
ISSN:
0891-5849
URN:
uuid:7be4165e-575e-4680-9804-d42d3c69c381
Source identifiers:
492019
Local pid:
pubs:492019

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