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Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.

Abstract:

Inducible nitric oxide synthase (iNOS) is a key enzyme in the macrophage inflammatory response, which is the source of nitric oxide (NO) that is potently induced in response to proinflammatory stimuli. However, the specific role of NO production, as distinct from iNOS induction, in macrophage inflammatory responses remains unproven. We have generated a novel mouse model with conditional deletion of Gch1, encoding GTP cyclohydrolase 1 (GTPCH), an essential enzyme in the biosynthesis of tetrahy...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.freeradbiomed.2014.10.575

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Oxford NIHR Biomedical Research Centre More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Free radical biology and medicine Journal website
Volume:
79
Pages:
206-216
Publication date:
2015-02-01
DOI:
EISSN:
1873-4596
ISSN:
0891-5849
Source identifiers:
492019
Language:
English
Keywords:
Pubs id:
pubs:492019
UUID:
uuid:7be4165e-575e-4680-9804-d42d3c69c381
Local pid:
pubs:492019
Deposit date:
2014-12-19

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