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Journal article

RNA splicing: disease and therapy.

Abstract:

The majority of human genes that encode proteins undergo alternative pre-mRNA splicing and mutations that affect splicing are more prevalent than previously thought. The mechanism of pre-mRNA splicing is highly complex, requiring multiple interactions between pre-mRNA, small nuclear ribonucleoproteins and splicing factor proteins. Regulation of this process is even more complicated, relying on loosely defined cis-acting regulatory sequence elements, trans-acting protein factors and cellular r...

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Publisher copy:
10.1093/bfgp/elr020

Authors


Douglas, AG More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Briefings in functional genomics
Volume:
10
Issue:
3
Pages:
151-164
Publication date:
2011-05-05
DOI:
EISSN:
2041-2657
ISSN:
2041-2649
URN:
uuid:7bd9ad4f-af62-4260-b08f-5be1d2140921
Source identifiers:
140316
Local pid:
pubs:140316

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