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Tumour necrosis factor-alpha increases extravasation of virus particles into tumour tissue by activating the Rho A/Rho kinase pathway.

Abstract:

Tumour Necrosis Factor alpha (TNF) is a pleiotropic pro-inflammatory cytokine with known vascular permeabilising activity. It is employed during isolated limb perfusion to enhance delivery of chemotherapeutic drugs into tumour tissue. The use of conditionally-replicating lytic viruses, so called 'oncolytic virotherapy', provides a new approach to cancer treatment that is currently limited by the low efficiency of extravasation of viral particles into tumours. We report here evidence that TNF ...

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Publication status:
Published

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Authors


Carroll, F More by this author
Illingworth, S More by this author
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Journal:
Journal of controlled release : official journal of the Controlled Release Society
Volume:
156
Issue:
3
Pages:
381-389
Publication date:
2011-12-05
DOI:
EISSN:
1873-4995
ISSN:
0168-3659
URN:
uuid:7bd95aaf-9b84-43b3-a852-55e3e735e18e
Source identifiers:
186432
Local pid:
pubs:186432

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