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Journal article

Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT.

Abstract:

Proton-dependent oligopeptide transporters (POTs) are major facilitator superfamily (MFS) proteins that mediate the uptake of peptides and peptide-like molecules, using the inwardly directed H(+) gradient across the membrane. The human POT family transporter peptide transporter 1 is present in the brush border membrane of the small intestine and is involved in the uptake of nutrient peptides and drug molecules such as β-lactam antibiotics. Although previous studies have provided insight into ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1301079110

Authors


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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
110
Issue:
28
Pages:
11343-11348
Publication date:
2013-07-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:7bd53539-6efe-497b-a9c8-0de3e7b71d03
Source identifiers:
415726
Local pid:
pubs:415726

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