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Ca2+-dependent interface formation in fibrillin-1.

Abstract:

The calcium-binding epidermal growth factor-like (cbEGF) domain is a common structural motif in extracellular and transmembrane proteins. K(d) values for Ca2+ vary from the millimolar to nanomolar range; however the molecular basis for this variation is poorly understood. We have measured K(d) values for six fibrillin-1 cbEGF domains, each preceded by a transforming growth factor beta-binding protein-like (TB) domain. Using NMR and titration with chromophoric chelators, we found that K(d) val...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m412832200

Authors


Jensen, SA More by this author
Corbett, AR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
The Journal of biological chemistry
Volume:
280
Issue:
14
Pages:
14076-14084
Publication date:
2005-04-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:7bd5104b-5d71-4400-9c2e-cb933feefecd
Source identifiers:
100060
Local pid:
pubs:100060

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