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An outpatient, ambulant-design, controlled human infection model using escalating doses of Salmonella Typhi challenge delivered in sodium bicarbonate solution.

Abstract:

BACKGROUND: Typhoid fever is a major global health problem, the control of which is hindered by lack of a suitable animal model in which to study Salmonella Typhi infection. Until 1974, a human challenge model advanced understanding of typhoid and was used in vaccine development. We set out to establish a new human challenge model and ascertain the S. Typhi (Quailes strain) inoculum required for an attack rate of 60%-75% in typhoid-naive volunteers when ingested with sodium bicarbonate soluti...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/cid/ciu078

Authors


Waddington, CS More by this author
Darton, TC More by this author
Haworth, K More by this author
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Wellcome Trust More from this funder
NIHR Oxford Biomedical Research Centre More from this funder
Jenner Institute More from this funder
Oxford Martin School More from this funder
National Institute of Allergy and Infectious Diseases More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Journal website
Volume:
58
Issue:
9
Pages:
1230-1240
Publication date:
2014-05-05
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
URN:
uuid:7bd2fe83-09b5-4cb4-a8bd-2639105693a1
Source identifiers:
449132
Local pid:
pubs:449132

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