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Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C.

Abstract:

HLA class I-mediated selection of immune escape mutations in functionally important Gag epitopes may partly explain slower disease progression in HIV-1-infected individuals with protective HLA alleles. To investigate the impact of Gag function on disease progression, the replication capacities of viruses encoding Gag-protease from 60 individuals in early HIV-1 subtype C infection were assayed in an HIV-1-inducible green fluorescent protein reporter cell line and were correlated with subsequen...

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Publisher copy:
10.1128/jvi.02520-10

Authors


Wright, JK More by this author
Novitsky, V More by this author
Brockman, MA More by this author
Brumme, ZL More by this author
Brumme, CJ More by this author
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Journal:
Journal of virology
Volume:
85
Issue:
8
Pages:
3996-4006
Publication date:
2011-04-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:7bc8539b-7980-4fe2-8eb3-363249093071
Source identifiers:
191284
Local pid:
pubs:191284

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