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Journal article

Expression of human CD46 and trans-complementation by murine adenovirus 1 fails to allow productive infection by a group B oncolytic adenovirus in murine cancer cells

Abstract:

Background

Oncolytic viruses are currently experiencing accelerated development in several laboratories worldwide, with some forty-seven clinical trials currently recruiting. Many oncolytic viruses combine targeted cytotoxicity to cancer cells with a proinflammatory cell lysis. Due to their additional potential to express immunomodulatory transgenes, they are also often known as oncolytic viral vaccines. However, several types of oncolytic viruses are human-specific and the lack ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s40425-018-0350-x

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
ORCID:
0000-0002-4436-360X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
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Linacre College, Oxford More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Journal for Immunotherapy of Cancer Journal website
Volume:
6
Issue:
1
Pages:
55
Publication date:
2018-06-13
Acceptance date:
2018-05-07
DOI:
EISSN:
2051-1426
ISSN:
2051-1426
Pubs id:
pubs:857316
URN:
uri:7bc3bfa3-faf0-43f0-9412-a10e9ab6f3bf
UUID:
uuid:7bc3bfa3-faf0-43f0-9412-a10e9ab6f3bf
Local pid:
pubs:857316

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