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Vaccination with the Staphylococcus aureus secreted proteins EapH1 and EapH2 impacts both S. aureus carriage and invasive disease

Abstract:

Introduction

There is a need for an efficacious vaccine reducing infections due to Staphylococcus aureus, a common cause of community and hospital infection. Infecting organisms originate from S. aureus populations colonising the nares and bowel. Antimicrobials are widely used to transiently reduce S. aureus colonisation prior to surgery, a practice which is selecting for resistant S. aureus isolates. S. aureus secretes multiple proteins, including the protease inhibitors extrace...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Elshina, E More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Jenner Institute
Oxford college:
Hertford College
Van Diemen, PM More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Jenner Institute
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Funding agency for:
Rollier, CS
National Institute for Health Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Vaccine Journal website
Volume:
37
Issue:
3
Pages:
502-509
Publication date:
2018-11-28
Acceptance date:
2018-11-13
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
Pubs id:
pubs:948390
URN:
uri:7bc368c3-3756-4724-a9ce-165a96230138
UUID:
uuid:7bc368c3-3756-4724-a9ce-165a96230138
Local pid:
pubs:948390
Language:
English
Keywords:

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