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Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

Abstract:

The emerging notion of environment-induced reprogramming of Foxp3(+) regulatory T (Treg) cells into helper T (Th) cells remains controversial. By genetic fate mapping or adoptive transfers, we have identified a minor population of nonregulatory Foxp3(+) T cells exhibiting promiscuous and transient Foxp3 expression, which gave rise to Foxp3(-) ("exFoxp3") Th cells and selectively accumulated in inflammatory cytokine milieus or in lymphopenic environments including those in early ontogeny. In c...

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Publication status:
Published

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Journal:
Immunity
Volume:
36
Issue:
2
Pages:
262-275
Publication date:
2012-02-01
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
Source identifiers:
321696

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