- Abstract:
-
The emerging notion of environment-induced reprogramming of Foxp3(+) regulatory T (Treg) cells into helper T (Th) cells remains controversial. By genetic fate mapping or adoptive transfers, we have identified a minor population of nonregulatory Foxp3(+) T cells exhibiting promiscuous and transient Foxp3 expression, which gave rise to Foxp3(-) ("exFoxp3") Th cells and selectively accumulated in inflammatory cytokine milieus or in lymphopenic environments including those in early ontogeny. In c...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.immuni.2011.12.012
-
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- Journal:
- Immunity
- Volume:
- 36
- Issue:
- 2
- Pages:
- 262-275
- Publication date:
- 2012-02-05
- DOI:
- EISSN:
-
1097-4180
- ISSN:
-
1074-7613
- URN:
-
uuid:7bab2e4c-2a28-4871-8d3c-2aec3e3ec81b
- Source identifiers:
-
321696
- Local pid:
- pubs:321696
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.
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