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Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia.

Abstract:

Therapy-related acute myeloid leukemia (t-AML) in most cases develops after chemotherapy of other malignancies and shows characteristic chromosome aberrations. Two general types of t-AML have previously been identified. One type is observed after therapy with alkylating agents and characteristically presents as therapy-related myelodysplasia with deletions or loss of the long arms of chromosomes 5 and 7 or loss of the whole chromosomes. The other type is observed after therapy with topoisomer...

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Publisher copy:
10.1182/blood.v99.6.1909

Authors


Pedersen-Bjergaard, J More by this author
Andersen, MK More by this author
Christiansen, DH More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences, Molecular Medicine
Journal:
Blood
Volume:
99
Issue:
6
Pages:
1909-1912
Publication date:
2002-03-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:7b97e1d6-3cdb-4157-b2fb-1420ea6de605
Source identifiers:
324034
Local pid:
pubs:324034

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