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Journal article

DNA fusion vaccines incorporating IL-23 or RANTES for use in immunization against influenza.

Abstract:

The incorporation of RANTES or IL-23 into DNA vaccines may improve their immunogenicity by the recruitment and activation of dendritic cells. This may also select for a TH1 response counteracting the TH2 response which can predominate when a DNA vaccine is delivered by gene gun. We have immunized mice with various DNA constructs encoding APR/8/34 influenza virus hemagglutinin (HA), either fused to or separate from, IL-23 or RANTES using a gene gun. Those immunized with IL-23/HA fusion constru...

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Publication status:
Published

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Authors


Williman, J More by this author
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Journal:
Vaccine
Volume:
26
Issue:
40
Pages:
5153-5158
Publication date:
2008-09-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:7b97c633-18aa-4d5a-b6ff-cf5cbb3d52bd
Source identifiers:
222824
Local pid:
pubs:222824

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