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Journal article

Synthesis of diverse 2,3-dihydroindoles, 1,2,3,4-tetrahydroquinolines, and benzo-fused azepines by formal radical cyclization onto aromatic rings.

Abstract:

2,3-Dihydroindoles, 1,2,3,4-tetrahydroquinolines, and 2,3,4,5-tetrahydrobenzo[b]azepines are available by a process that represents formal radical cyclization onto aromatic rings. Optically pure benzo-fused heterocycles are also accessible by this method. p-Iodophenols, especially those with the phenolic oxygen protected as a MOM-ether, can be coupled with amino alcohols to produce N-aryl amino alcohols, which can be converted into the corresponding alkyl iodides in which the nitrogen is prot...

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Publication status:
Published

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Publisher copy:
10.1021/jo7026307

Authors


Fletcher, SP More by this author
Ziffle, VE More by this author
Wingert, D More by this author
Journal:
The Journal of organic chemistry
Volume:
73
Issue:
6
Pages:
2330-2344
Publication date:
2008-03-05
DOI:
EISSN:
1520-6904
ISSN:
0022-3263
URN:
uuid:7b8a6466-ab12-484f-99bc-8e3d64b186d5
Source identifiers:
117863
Local pid:
pubs:117863

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