Journal article icon

Journal article

Does memory improve with age? CD85j (ILT-2/LIR-1) expression on CD8 T cells correlates with 'memory inflation' in human cytomegalovirus infection.

Abstract:

CMV-specific memory CD8(+) T cells accumulate over time to reach high frequencies amongst peripheral blood lymphocytes - a phenomenon termed 'memory inflation'. Using tetramer staining on samples from a large number of subjects and multivariate regression analysis, we were able to relate this to the phenotype of CD8(+) T cells. We made the following observations: (i) CD85j (ILT-2/LIR-1) was highly expressed alongside CD57 - an established effector memory marker - on CMV-specific CD8(+) T cell...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Northfield, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Journal:
Immunology and cell biology
Volume:
83
Issue:
2
Pages:
182-188
Publication date:
2005-04-05
DOI:
EISSN:
1440-1711
ISSN:
0818-9641
URN:
uuid:7b8a33de-f462-4b10-a36c-d2b1c0add322
Source identifiers:
13483
Local pid:
pubs:13483

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP