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Does memory improve with age? CD85j (ILT-2/LIR-1) expression on CD8 T cells correlates with 'memory inflation' in human cytomegalovirus infection.

Abstract:

CMV-specific memory CD8(+) T cells accumulate over time to reach high frequencies amongst peripheral blood lymphocytes - a phenomenon termed 'memory inflation'. Using tetramer staining on samples from a large number of subjects and multivariate regression analysis, we were able to relate this to the phenotype of CD8(+) T cells. We made the following observations: (i) CD85j (ILT-2/LIR-1) was highly expressed alongside CD57 - an established effector memory marker - on CMV-specific CD8(+) T cell...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Immunology and cell biology
Volume:
83
Issue:
2
Pages:
182-188
Publication date:
2005-04-01
DOI:
EISSN:
1440-1711
ISSN:
0818-9641
Source identifiers:
13483
Language:
English
Keywords:
Pubs id:
pubs:13483
UUID:
uuid:7b8a33de-f462-4b10-a36c-d2b1c0add322
Local pid:
pubs:13483
Deposit date:
2012-12-19

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