- Abstract:
-
Structure-based vaccine design has been used to develop immunogens that display conserved neutralization sites on pathogens such as HIV-1, respiratory syncytial virus (RSV), and influenza. Improving the immunogenicity of these designed immunogens with adjuvants will require formulations that do not alter protein antigenicity. Here, we show that nanoparticle-forming thermoresponsive polymers (TRP) allow for co-delivery of RSV fusion (F) protein trimers with Toll-like receptor 7 and 8 agonists ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1021/acs.bioconjchem.6b00370
-
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- Grant:
- National Sustainability Program II (project BIOCEV-FAR LQ1604)
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Bioconjugate Chemistry Journal website
- Volume:
- 27
- Issue:
- 10
- Pages:
- 2372-2385
- Publication date:
- 2016-10-19
- DOI:
- EISSN:
-
1520-4812
- ISSN:
-
1043-1802
- Pubs id:
-
pubs:653607
- URN:
-
uri:7b8766f2-4859-43a8-8d13-a09da4d9dac7
- UUID:
-
uuid:7b8766f2-4859-43a8-8d13-a09da4d9dac7
- Local pid:
- pubs:653607
- Paper number:
- 10
- Language:
- English
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 American Chemical Society.
Journal article
Thermoresponsive polymer nanoparticles co-deliver RSV F trimers with a TLR-7/8 adjuvant
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Vaccine
Research Center
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+ Ministry of Education, Youth and Sports of the Czech Republic
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