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Journal article

Thermoresponsive polymer nanoparticles co-deliver RSV F trimers with a TLR-7/8 adjuvant

Abstract:

Structure-based vaccine design has been used to develop immunogens that display conserved neutralization sites on pathogens such as HIV-1, respiratory syncytial virus (RSV), and influenza. Improving the immunogenicity of these designed immunogens with adjuvants will require formulations that do not alter protein antigenicity. Here, we show that nanoparticle-forming thermoresponsive polymers (TRP) allow for co-delivery of RSV fusion (F) protein trimers with Toll-like receptor 7 and 8 agonists ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Vaccine Research Center More from this funder
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Grant:
National Sustainability Program II (project BIOCEV-FAR LQ1604)
Publisher:
American Chemical Society Publisher's website
Journal:
Bioconjugate Chemistry Journal website
Volume:
27
Issue:
10
Pages:
2372-2385
Publication date:
2016-10-19
DOI:
EISSN:
1520-4812
ISSN:
1043-1802
Pubs id:
pubs:653607
URN:
uri:7b8766f2-4859-43a8-8d13-a09da4d9dac7
UUID:
uuid:7b8766f2-4859-43a8-8d13-a09da4d9dac7
Local pid:
pubs:653607
Paper number:
10
Language:
English

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