Journal article icon

Journal article

Direct interaction of Na-azide with the KATP channel.

Abstract:

1. The effects of the metabolic inhibitor sodium azide were tested on excised macropatches from Xenopus oocytes expressing cloned ATP-sensitive potassium (KATP) channels of the Kir6.2/SUR1 type. 2. In inside-out patches from oocytes expressing Kir6.2 delta C36 (a truncated form of Kir6.2 that expresses in the absence of SUR), intracellular Na-azide inhibited macroscopic currents with an IC50 of 11 mM. The inhibitory effect of Na-azide was mimicked by the same concentration of NaCl, but not by...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/sj.bjp.0703680

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
British journal of pharmacology
Volume:
131
Issue:
6
Pages:
1105-1112
Publication date:
2000-11-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:7b854ffd-f5de-41f1-abb9-ae4b5fbe50b1
Source identifiers:
113481
Local pid:
pubs:113481

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP