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Long-term decay of the HIV-1 reservoir in HIV-1-infected children treated with highly active antiretroviral therapy.

Abstract:

To investigate the decay of the human immunodeficiency virus type 1 (HIV-1) reservoir in children receiving highly active antiretroviral therapy (HAART), we measured HIV-1 DNA in peripheral blood mononuclear cells from 14 children who achieved and maintained suppression of plasma viremia up to 48 months after the initiation of HAART. Levels of intracellular unspliced and multiply spliced HIV-1 RNA were used as markers of residual viral replication. During the first month of HAART, there were ...

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Publication status:
Published

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Publisher copy:
10.1086/504264

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Journal:
Journal of infectious diseases
Volume:
193
Issue:
12
Pages:
1718-1727
Publication date:
2006-06-01
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Source identifiers:
422711
Language:
English
Keywords:
Pubs id:
pubs:422711
UUID:
uuid:7b844cfc-f05d-4ad9-8164-07c3f7835fd3
Local pid:
pubs:422711
Deposit date:
2014-02-08

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