- Abstract:
-
Interferon stimulates the expression of a number of genes encoding enzymes with antiviral activities, including myxovirus resistance-1 (MxA), 2-5-oligoadenylate synthetase 1 (OAS-1) and double-stranded RNA-dependent protein kinase (PKR). We examined whether polymorphisms in these genes influenced the outcome of hepatitis C virus (HCV) infection. We observed a lower frequency of the GG genotype at position -88 in the MxA gene promoter in self-limiting HCV infection (OR=0.56; 95% CI: 0.35-0.8; ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/sj.gene.6363984
-
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- Journal:
- Genes and immunity
- Volume:
- 4
- Issue:
- 6
- Pages:
- 411-419
- Publication date:
- 2003-09-05
- DOI:
- EISSN:
-
1476-5470
- ISSN:
-
1466-4879
- URN:
-
uuid:7b7b534d-741d-4552-9240-e00ab03abc7c
- Source identifiers:
-
38781
- Local pid:
- pubs:38781
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR.
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