Journal article icon

Journal article

Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles.

Abstract:

Experimental evidence implicates tumor necrosis factor (TNF) in the pathogenesis of malarial anemia, but there are few data relating to this hypothesis. This study found that severely anemic children with Plasmodium falciparum infection have low plasma TNF levels, in contrast to the high levels found in cerebral malaria. A previous case-control study in The Gambia found cerebral malaria, but not severe malarial anemia, was associated with the TNF-308 A allele. This study found that in the sam...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1086/314533

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Role:
Author
Expand authors...
Journal:
The Journal of infectious diseases
Volume:
179
Issue:
1
Pages:
287-290
Publication date:
1999-01-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:7b77e9fe-8846-42ba-b1ad-6217518f3e06
Source identifiers:
21870
Local pid:
pubs:21870

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP