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Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles.

Abstract:

Experimental evidence implicates tumor necrosis factor (TNF) in the pathogenesis of malarial anemia, but there are few data relating to this hypothesis. This study found that severely anemic children with Plasmodium falciparum infection have low plasma TNF levels, in contrast to the high levels found in cerebral malaria. A previous case-control study in The Gambia found cerebral malaria, but not severe malarial anemia, was associated with the TNF-308 A allele. This study found that in the sam...

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Publication status:
Published

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Publisher copy:
10.1086/314533

Authors


McGuire, W More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Allsopp, CE More by this author
Greenwood, BM More by this author
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Journal:
The Journal of infectious diseases
Volume:
179
Issue:
1
Pages:
287-290
Publication date:
1999-01-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:7b77e9fe-8846-42ba-b1ad-6217518f3e06
Source identifiers:
21870
Local pid:
pubs:21870

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