Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles.

Journal article

Experimental evidence implicates tumor necrosis factor (TNF) in the pathogenesis of malarial anemia, but there are few data relating to this hypothesis. This study found that severely anemic children with Plasmodium falciparum infection have low plasma TNF levels, in contrast to the high levels found in cerebral malaria. A previous case-control study in The Gambia found cerebral malaria, but not severe malarial anemia, was associated with the TNF-308 A allele. This study found that in the sam...

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Authors: McGuire, W; Knight, J; Hill, A; Allsopp, C; Greenwood, B

• Publication status: Published
• Journal: Journal of infectious diseases
• Volume: 179
• Issue: 1
• Pages: 287-290
• Publication date: 1999-01-01
• DOI: 10.1086/314533
• EISSN: 1537-6613
• ISSN: 0022-1899
• Language: English
• Keywords: Tumor Necrosis Factor-alpha; Malaria, Falciparum; Promoter Regions, Genetic; Humans; Alleles; Child, Preschool; HLA Antigens; Base Sequence; Case-Control Studies; Anemia; Gambia; Child; DNA Primers; Malaria, Cerebral