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Journal article

Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC.

Abstract:

Binding of the chromatin remodeling complex NoRC to RNA complementary to the rDNA promoter mediates transcriptional repression. TIP5, the largest subunit of NoRC, is involved in recruitment to rDNA by interactions with promoter-bound TTF-I, pRNA, and acetylation of H4K16. TIP5 domains that recognize posttranslational modifications on histones are essential for recruitment of NoRC to chromatin, but how these reader modules recognize site-specific histone tails has remained elusive. Here, we re...

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Publication status:
Published

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Publisher copy:
10.1016/j.str.2014.10.017

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Target Discovery Institute
Role:
Author
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Journal:
Structure (London, England : 1993)
Volume:
23
Issue:
1
Pages:
80-92
Publication date:
2015-01-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:7b761937-45a2-425a-8b81-2df5e55e4cec
Source identifiers:
500912
Local pid:
pubs:500912

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