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An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses.

Abstract:

Inhibitors of the protease of HIV-1 have been used successfully for the treatment of HIV-1-infected patients and AIDS disease. We tested whether these protease inhibitory drugs exerted effects in addition to their antiviral activity. Here, we show in mice infected with lymphocytic choriomeningitis virus and treated with the HIV-1 protease inhibitor ritonavir a marked inhibition of antiviral cytotoxic T lymphocyte (CTL) activity and impaired major histocompatibility complex class I-restricted ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.95.22.13120

Authors


Groettrup, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
de Giuli, R More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
95
Issue:
22
Pages:
13120-13124
Publication date:
1998-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:7b706837-c6a8-4dd9-9ad6-8e712a62d7b2
Source identifiers:
29858
Local pid:
pubs:29858

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