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The genetic landscape of renal complications in type 1 diabetes.

Abstract:

Diabetes is the leading cause of ESRD. Despite evidence for a substantial heritability of diabetic kidney disease, efforts to identify genetic susceptibility variants have had limited success. We extended previous efforts in three dimensions, examining a more comprehensive set of genetic variants in larger numbers of subjects with type 1 diabetes characterized for a wider range of cross-sectional diabetic kidney disease phenotypes. In 2843 subjects, we estimated that the heritability of diabe...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1681/ASN.2016020231

Authors


Sandholm, N More by this author
More by this author
Department:
Oxford, MSD, RDM, RDM OCDEM
Ahlqvist, E More by this author
Juliusdottir, T More by this author
Deshmukh, HA More by this author
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Seventh Framework Programme More from this funder
Publisher:
American Society for Nephrology Publisher's website
Journal:
Journal of the American Society of Nephrology Journal website
Volume:
28
Issue:
2
Publication date:
2016-09-05
Acceptance date:
2016-07-17
DOI:
ISSN:
1046-6673 and 1533-3450
Pubs id:
pubs:645829
URN:
uri:7b6e8ff1-34e2-43a4-bcb8-3734fd36e010
UUID:
uuid:7b6e8ff1-34e2-43a4-bcb8-3734fd36e010
Local pid:
pubs:645829

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