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New GM1 Ganglioside Derivatives for Selective Single and Double Labelling of the Natural Glycosphingolipid Skeleton

Abstract:

Selective single and double labelling of the natural ganglioside GM1. enables one to introduce various markers into different parts of the glycosphingolipid molecule without changing the natural skeleton. To that end, N-Fmoc-2amino-, N-Fmoc-18-amino- and S-(ethoxythiocarbonyl)-18mercaptostearic acids have been prepared, and. coupled with the primary amino group in the sphingosine part of lyso-GM1 and. deAc-deAcyl-GM1. gangliosides. The products of these coupling reactions - building blocks 16...

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Publication status:
Published

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Publisher copy:
10.1002/ejoc.200900645

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Role:
Author
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Journal:
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume:
2009
Issue:
30
Pages:
5162-5177
Publication date:
2009-10-05
DOI:
EISSN:
1099-0690
ISSN:
1434-193X
URN:
uuid:7b55410f-2256-4016-b6b3-f792835b5c21
Source identifiers:
222226
Local pid:
pubs:222226

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