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Autophagy in the renewal, differentiation and homeostasis of immune cells

Abstract:

Across all branches of the immune system, the process of autophagy is fundamentally important in cellular development, function and homeostasis. Strikingly, this evolutionarily ancient pathway for intracellular recycling has been adapted to enable a high degree of functional complexity and specialization. However, although the requirement for autophagy in normal immune cell function is clear, the mechanisms involved are much less so and encompass control of metabolism, selective degradation o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41577-018-0095-2

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
ORCID:
0000-0003-2846-7860
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
ORCID:
0000-0003-2846-7860
Publisher:
Springer Nature Publisher's website
Journal:
Nature Reviews Immunology Journal website
Volume:
19
Pages:
170–183
Publication date:
2018-12-07
Acceptance date:
2018-11-01
DOI:
EISSN:
1474-1741
ISSN:
1474-1733
Pubs id:
pubs:951334
URN:
uri:7b37051d-6dd0-4548-85b7-8fffe43ed4e1
UUID:
uuid:7b37051d-6dd0-4548-85b7-8fffe43ed4e1
Local pid:
pubs:951334
Language:
English

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