Journal article
Multi-compartment encapsulation of communicating droplets and droplet networks in hydrogel as a model for artificial cells.
- Abstract:
- Constructing a cell mimic is a major challenge posed by synthetic biologists. Efforts to this end have been primarily focused on lipid- and polymer-encapsulated containers, liposomes and polymersomes, respectively. Here, we introduce a multi-compartment, nested system comprising aqueous droplets stabilized in an oil/lipid mixture, all encapsulated in hydrogel. Functional capabilities (electrical and chemical communication) were imparted by protein nanopores spanning the lipid bilayer formed at the interface of the encapsulated aqueous droplets and the encasing hydrogel. Crucially, the compartmentalization enabled the formation of two adjoining lipid bilayers in a controlled manner, a requirement for the realization of a functional protocell or prototissue.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.3MB, Terms of use)
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- Publisher copy:
- 10.1038/srep45167
Authors
- Publisher:
- Nature Publishing Group
- Journal:
- Scientific Reports More from this journal
- Volume:
- 7
- Pages:
- 45167
- Publication date:
- 2017-04-01
- Acceptance date:
- 2017-02-20
- DOI:
- EISSN:
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2045-2322
- Pmid:
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28367984
- Language:
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English
- Keywords:
- Pubs id:
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pubs:688755
- UUID:
-
uuid:7b2f4253-a5c7-462e-ba9d-3d337ddc5180
- Local pid:
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pubs:688755
- Source identifiers:
-
688755
- Deposit date:
-
2017-10-19
Terms of use
- Copyright holder:
- Bayley et al
- Copyright date:
- 2017
- Notes:
- © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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