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Prostaglandin D2 and leukotriene E4 synergize to stimulate diverse TH2 functions and TH2 cell/neutrophil crosstalk.

Abstract:

BACKGROUND: Prostaglandin D2 (PGD2) and cysteinyl leukotrienes (cysLTs) are lipid mediators derived from mast cells, which activate TH2 cells. The combination of PGD2 and cysLTs (notably cysteinyl leukotriene E4 [LTE4]) enhances TH2 cytokine production. However, the synergistic interaction of cysLTs with PGD2 in promoting TH2 cell activation is still poorly understood. The receptors for these mediators are drug targets in the treatment of allergic diseases, and hence understanding their inter...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jaci.2014.09.006

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division
Fergusson, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Radcliffe Department of Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division
Ussher, JE More by this author
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Publisher:
Elsevier Publisher's website
Journal:
The Journal of allergy and clinical immunology Journal website
Volume:
135
Issue:
5
Pages:
1358-1366.e11
Publication date:
2015-05-05
DOI:
EISSN:
1097-6825
ISSN:
0091-6749
URN:
uuid:7b2bf6ee-fce2-4a3e-9160-593bccdd249c
Source identifiers:
491992
Local pid:
pubs:491992

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