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CD161 defines a functionally distinct subset of pro-inflammatory natural killer cells

Abstract:

CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells; however, the significance of CD161 expression on NK cells has not been comprehensively investigated. Recently, we found that CD161 expression identifies a transcriptional and innate functional phenotype that is shared across various T cell populations. Using mass cytometry and microarray experiments, we demonstrate that this functional phenotype extends to NK cells. CD161 marks NK cells that have re...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fimmu.2018.00486

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
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Swiss National Science Foundation More from this funder
Medical Research Council More from this funder
Oxford Biomedical Research Centre More from this funder
Nuffield Department of Clinical Medicine More from this funder
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Pages:
486
Publication date:
2018-04-09
Acceptance date:
2018-02-23
DOI:
ISSN:
1664-3224
Pubs id:
pubs:842508
URN:
uri:7b1cfa40-41ce-4bac-9cb5-b89d864e3336
UUID:
uuid:7b1cfa40-41ce-4bac-9cb5-b89d864e3336
Local pid:
pubs:842508

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