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Journal article

NOD2-mediated autophagy and Crohn disease.

Abstract:

Autophagy is important in immune cells as a means of disposing of pathogens and in connecting with the antigen presentation machinery to facilitate immune priming and initiation of a correctly targeted adaptive immune response. While Toll-like receptors (TLRs) are known to regulate autophagy in this context, the extent to which other pattern recognition receptors (PRRs) are involved has been unclear. NOD2 is an intracellular PRR of the Nod-like receptor (NLR) family that is notable in that va...

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Publication status:
Published

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Publisher copy:
10.4161/auto.6.3.11389

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Molecular Medicine
Role:
Author
Journal:
Autophagy
Volume:
6
Issue:
3
Pages:
412-414
Publication date:
2010-04-05
DOI:
EISSN:
1554-8635
ISSN:
1554-8627
URN:
uuid:7af79032-7904-4fe8-95b8-c11e5fa6d570
Source identifiers:
50314
Local pid:
pubs:50314

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