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LAZ3 rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients.

Abstract:

We have recently shown that an evolutionary conserved gene LAZ3, encoding a zinc finger protein, is disrupted and overexpressed in some B-cell lymphomas (mainly with a large cell component) that show chromosomal rearrangements involving 3q27. Because the breakpoints involved in these rearrangements are focused in a narrow major translocation cluster (MTC) on chromosome 3, we used genomic probes from this region to study the molecular rearrangements of LAZ3 in a large series of patients (217) ...

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Publication status:
Published

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Authors


Bastard, C More by this author
Deweindt, C More by this author
Kerckaert, JP More by this author
Lenormand, B More by this author
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Journal:
Blood
Volume:
83
Issue:
9
Pages:
2423-2427
Publication date:
1994-05-05
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:7af47d52-21cb-400e-97c1-2dc0c20d99b8
Source identifiers:
486730
Local pid:
pubs:486730

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