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Molecular characterisation of autophagy deficits in a LRRK2-BAC transgenic rat model of Parkinson’s disease

Abstract:

Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide. PD is characterised by the preferential loss of dopaminergic neurons in the Substantia Nigra pars compacta in the midbrain accompanied by progressive motor dysfunction. The precise aetiology of PD is unknown, however a causative role of Leucine-rich repeat kinase 2 (LRRK2) has been proposed. Mutations in the LRRK2 gene are the most frequent cause of familial PD and are also an independent risk factor f...

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Supervisor
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Supervisor
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Grant:
J-1403
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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