Thesis
Molecular characterisation of autophagy deficits in a LRRK2-BAC transgenic rat model of Parkinson’s disease
- Abstract:
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Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide. PD is characterised by the preferential loss of dopaminergic neurons in the Substantia Nigra pars compacta in the midbrain accompanied by progressive motor dysfunction. The precise aetiology of PD is unknown, however a causative role of Leucine-rich repeat kinase 2 (LRRK2) has been proposed. Mutations in the LRRK2 gene are the most frequent cause of familial PD and are also an independent risk factor f...
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Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
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uuid:7af0e93f-56cd-49cd-983d-1becc875351f
- Deposit date:
- 2019-01-08
Terms of use
- Copyright holder:
- Wallings, R
- Copyright date:
- 2018
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