Serial immunoprecipitation assays for interferon--(IFN)-beta antibodies in multiple sclerosis patients.

Lampasona, V; Rio, J; Franciotta, D; Furlan, R; Avolio, C; Fazio, R; Lavolpe, V; Vincent, A; Comi, G; Trojano, M; Montalban, X; Martino, G

Abstract:

We devised a sensitive, radioimmunoprecipitation assay (RIPA) for anti-interferon (IFN)-beta-binding antibody (BAB) detection. Our RIPA showed good agreement with a reference RIPA (mean difference, -3.2 +/- 10.6 AU), and detected BAB to both IFN-beta-1a and IFN-beta-1b. Neutralizing antibodies to IFN-b (NAB) were also determined with a standard method. BAB and NAB were measured in 393 serum samples from 77 multiple sclerosis (MS) patients treated with IFN-beta-1a or -1b, who were studied over...

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APA Style

Lampasona, V., Rio, J., Franciotta, D., Furlan, R., Avolio, C., Fazio, R., Lavolpe, V., Vincent, A., Comi, G., Trojano, M., Montalban, X., & Martino, G. (2003). Serial immunoprecipitation assays for interferon--(IFN)-beta antibodies in multiple sclerosis patients. European Cytokine Network, 14(3), 154–157.

MLA Style

Lampasona, V., et al. “Serial Immunoprecipitation Assays for Interferon--(IFN)-Beta Antibodies in Multiple Sclerosis Patients.” European Cytokine Network, vol. 14, no. 3, 2003, pp. 154–57.

Chicago Style

Lampasona, V, J Rio, D Franciotta, R Furlan, C Avolio, R Fazio, V Lavolpe, et al. 2003. “Serial Immunoprecipitation Assays for Interferon--(IFN)-Beta Antibodies in Multiple Sclerosis Patients.” European Cytokine Network 14 (3): 154–57.
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