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Nonopsonic phagocytosis of Pseudomonas aeruginoas: insights from an infant with leukocyte adhesion deficiency.

Abstract:

Children with leukocyte adhesion deficiency type I are at risk for overwhelming infection because their neutrophils lack surface beta 2 integrins (CD18/CD11) that normally interact with endothelial cell adhesion molecules and mediate migration to sites of bacterial invasion. In vitro studies of phagocytic cells from an infant with leukocyte adhesion deficiency type I demonstrated that complement receptor 3 (CD18/CD11b) mediates nonopsonic phagocytosis of some Pseudomonas aeruginosa strains an...

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Publication status:
Published

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Publisher copy:
10.1097/00006454-200104000-00019

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
Journal:
Pediatric infectious disease journal More from this journal
Volume:
20
Issue:
4
Pages:
452-454
Publication date:
2001-04-01
DOI:
EISSN:
1532-0987
ISSN:
0891-3668
Language:
English
Keywords:
Pubs id:
pubs:122038
UUID:
uuid:7ae939d4-0faf-4ebf-9780-7f7c34b8235c
Local pid:
pubs:122038
Source identifiers:
122038
Deposit date:
2012-12-19

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