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Nonopsonic phagocytosis of Pseudomonas aeruginoas: insights from an infant with leukocyte adhesion deficiency.

Abstract:

Children with leukocyte adhesion deficiency type I are at risk for overwhelming infection because their neutrophils lack surface beta 2 integrins (CD18/CD11) that normally interact with endothelial cell adhesion molecules and mediate migration to sites of bacterial invasion. In vitro studies of phagocytic cells from an infant with leukocyte adhesion deficiency type I demonstrated that complement receptor 3 (CD18/CD11b) mediates nonopsonic phagocytosis of some Pseudomonas aeruginosa strains an...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics, Biomedical Research Centre
Massing, B More by this author
Speert, DP More by this author
Journal:
The Pediatric infectious disease journal
Volume:
20
Issue:
4
Pages:
452-454
Publication date:
2001-04-05
DOI:
EISSN:
1532-0987
ISSN:
0891-3668
URN:
uuid:7ae939d4-0faf-4ebf-9780-7f7c34b8235c
Source identifiers:
122038
Local pid:
pubs:122038

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