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Palladium-mediated cell-surface labeling.

Abstract:
Benign C-C bond formation at various sites in cell-surface channels has been achieved through Suzuki-Miyaura coupling of genetically positioned unnatural amino acids containing aryl halide side chains. This enabled site-selective cell surface manipulation of Escherichia coli ; the phosphine-free catalyst caused no cell death at required Pd loadings, suggesting future in vivo application of catalytic metal-mediated bond formation in more complex organisms.
Publication status:
Published

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Publisher copy:
10.1021/ja209352s

Authors


Spicer, CD More by this author
Triemer, T More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Journal of the American Chemical Society
Volume:
134
Issue:
2
Pages:
800-803
Publication date:
2012-01-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:7ad30bc8-9cb7-422c-8b55-701eed5d18df
Source identifiers:
237341
Local pid:
pubs:237341

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