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Melanocyte-specific gene expression: role of repression and identification of a melanocyte-specific factor, MSF.

Abstract:

For a gene to be transcribed in a tissue-specific fashion, expression must be achieved in the appropriate cell type and also be prevented in other tissues. As an approach to understanding the regulation of tissue-specific gene expression, we have analyzed the requirements for melanocyte-specific expression of the tyrosinase-related protein 1 (TRP-1) promoter. Positive regulation of TRP-1 expression is mediated by both an octamer-binding motif and an 11-bp element, termed the M box, which is c...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
Journal:
Molecular and cellular biology
Volume:
14
Issue:
5
Pages:
3494-3503
Publication date:
1994-05-01
EISSN:
1098-5549
ISSN:
0270-7306
Source identifiers:
92928

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