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Melanocyte-specific gene expression: role of repression and identification of a melanocyte-specific factor, MSF.

Abstract:

For a gene to be transcribed in a tissue-specific fashion, expression must be achieved in the appropriate cell type and also be prevented in other tissues. As an approach to understanding the regulation of tissue-specific gene expression, we have analyzed the requirements for melanocyte-specific expression of the tyrosinase-related protein 1 (TRP-1) promoter. Positive regulation of TRP-1 expression is mediated by both an octamer-binding motif and an 11-bp element, termed the M box, which is c...

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Publication status:
Published

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Authors


Yavuzer, U More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
Journal:
Molecular and cellular biology
Volume:
14
Issue:
5
Pages:
3494-3503
Publication date:
1994-05-05
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:7abdb351-9510-4cd9-b031-a8e0a016d5e3
Source identifiers:
92928
Local pid:
pubs:92928

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