Journal article icon

Journal article

Telomere maintenance: all's well that ends well.

Abstract:

The nucleoprotein structures termed telomeres serve to prevent the mis-identification of eukaryotic chromosome ends as sites of DNA damage, but are also among the genomic regions that pose the most problems during DNA replication. Here, we summarize some of the apparent difficulties encountered by the DNA replication machinery when it approaches the chromosome ends. Eukaryotic cells have evolved diverse mechanisms to overcome these problems, underlining the importance of telomere maintenance ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1007/s00204-009-0423-1

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Archives of toxicology
Volume:
83
Issue:
5
Pages:
407-416
Publication date:
2009-05-05
DOI:
EISSN:
1432-0738
ISSN:
0340-5761
URN:
uuid:7ab6812d-072c-47bb-9774-865d7d63f947
Source identifiers:
11346
Local pid:
pubs:11346

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP