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Telomere maintenance: all's well that ends well.

Abstract:

The nucleoprotein structures termed telomeres serve to prevent the mis-identification of eukaryotic chromosome ends as sites of DNA damage, but are also among the genomic regions that pose the most problems during DNA replication. Here, we summarize some of the apparent difficulties encountered by the DNA replication machinery when it approaches the chromosome ends. Eukaryotic cells have evolved diverse mechanisms to overcome these problems, underlining the importance of telomere maintenance ...

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Publication status:
Published

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Publisher copy:
10.1007/s00204-009-0423-1

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Archives of toxicology
Volume:
83
Issue:
5
Pages:
407-416
Publication date:
2009-05-01
DOI:
EISSN:
1432-0738
ISSN:
0340-5761
Source identifiers:
11346
Language:
English
Keywords:
Pubs id:
pubs:11346
UUID:
uuid:7ab6812d-072c-47bb-9774-865d7d63f947
Local pid:
pubs:11346
Deposit date:
2012-12-19

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