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Journal article

Beneficial and harmful effects of anthracyclines in the treatment of childhood acute lymphoblastic leukaemia: a systematic review and meta-analysis.

Abstract:

Anthracyclines are used to treat childhood acute lymphoblastic leukaemia (ALL) but non-randomized studies suggest that cardiotoxicity may be a problem. Individual patient data from trials in childhood ALL that randomized anthracyclines or methods of reducing cardiotoxicity were analysed by standard meta-analysis methods. Results were grouped and combined according to: addition of an anthracycline to standard therapy, type of anthracycline, mode of administration, and the use of a cardioprotec...

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Publication status:
Published

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Journal:
British journal of haematology
Volume:
145
Issue:
3
Pages:
376-388
Publication date:
2009-05-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:7aa8f4fa-5c91-4d7e-ab87-b668602e4739
Source identifiers:
66819
Local pid:
pubs:66819

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