Risk factors for high cerebral blood flow velocity and death in Kenyan children with Sickle Cell Anaemia: role of haemoglobin oxygen saturation and febrile illness.

Journal article

High cerebral blood flow velocity (CBFv) and low haemoglobin oxygen saturation (SpO(2)) predict neurological complications in sickle cell anaemia (SCA) but any association is unclear. In a cross-sectional study of 105 Kenyan children, mean CBFv was 120 +/- 34.9 cm/s; 3 had conditional CBFv (170-199 cm/s) but none had abnormal CBFv (>200 cm/s). After adjustment for age and haematocrit, CBFv > or =150 cm/s was predicted by SpO(2) < or = 95% and history of fever. Four years later, 10 ch...

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Authors: Makani, J; Kirkham, F; Komba, A; Ajala-Agbo, T; Otieno, G

• Publication status: Published
• Journal: British journal of haematology
• Volume: 145
• Issue: 4
• Pages: 529-532
• Publication date: 2009-05-01
• DOI: 10.1111/j.1365-2141.2009.07660.x
• EISSN: 1365-2141
• ISSN: 0007-1048
• Language: English
• Keywords: Blood Flow Velocity; Fever; Child; Cross-Sectional Studies; Hematocrit; Ultrasonography, Doppler, Transcranial; Oxygen; Kenya; Child, Preschool; Stroke; Oximetry; Risk; Cerebrovascular Circulation; Multivariate Analysis; Hemoglobins; Humans; Anemia, Sickle Cell; Odds Ratio; Risk Factors