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A THEORETICAL FRAMEWORK FOR SELF-TOLERANCE AND ITS RELEVANCE TO THERAPY OF AUTOIMMUNE-DISEASE

Abstract:

Therapeutic intervention in autoimmune diseases should be based on a knowledge of how the normal immune system maintains unresponsiveness to 'self' and how this state of unresponsiveness may be broken. We have proposed that 'self' from the viewpoint of T cells may represent only a small fraction of the peptides that are available in the body. These would be the peptides that successfully access MHC molecules on a limited number of antigen presenting cells. As the number of self peptides is fa...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
JOURNAL OF AUTOIMMUNITY
Volume:
1
Issue:
6
Pages:
623-629
Publication date:
1988-12-05
DOI:
EISSN:
1095-9157
ISSN:
0896-8411
URN:
uuid:7aa4aebd-ef79-473d-bed7-da0cd2ed2254
Source identifiers:
5162
Local pid:
pubs:5162
Language:
English

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