Thesis
Understanding the role of C16orf72 in the DNA replication stress response
- Abstract:
-
The human genome continually undergoes DNA damage that is endogenous and exogenous in origin. To protect the genome from this DNA damage, cells have evolved a plethora of signalling pathways, known as the DNA damage response (DDR). The poly(ADP-ribose) polymerase (PARP) enzyme family can regulate a variety of DDR pathways by modifying substrates with ADP-ribose, a type of chemical post-translational modification. However, our understanding of these pathways, and the factors involved in the...
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Authors
Contributors
+ Gibbs-Seymour, I
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
+ Lakin, N
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
+ Pears, C
Role:
Supervisor
Funding
+ AstraZeneca
More from this funder
Funder identifier:
http://dx.doi.org/10.13039/100004325
Programme:
BBSRC iCASE Studentship
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2023-06-13
Terms of use
- Copyright holder:
- Kosmin, J
- Copyright date:
- 2022
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