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Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination.

Abstract:

Nonreplicating adenovirus vectors are being developed as vehicles for the delivery of therapeutic genes in vivo. Whereas in many organs an antiviral T cell response eliminates the vector and damages local tissue, when adenovirus vectors are injected into the brain the subsequent immune attack can be ineffective, allowing the vector to persist. In the present study, E1-deleted human adenovirus vectors were injected into the caudate nucleus of rats. Two months later, expression of protein from ...

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Authors


Byrnes, AP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Biomedical Research Centre
Charlton, HM More by this author
Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
16
Issue:
9
Pages:
3045-3055
Publication date:
1996-05-05
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:7a9e0bf1-4ab8-4978-933f-b4a198d91aad
Source identifiers:
397141
Local pid:
pubs:397141

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