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Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination.

Abstract:

Nonreplicating adenovirus vectors are being developed as vehicles for the delivery of therapeutic genes in vivo. Whereas in many organs an antiviral T cell response eliminates the vector and damages local tissue, when adenovirus vectors are injected into the brain the subsequent immune attack can be ineffective, allowing the vector to persist. In the present study, E1-deleted human adenovirus vectors were injected into the caudate nucleus of rats. Two months later, expression of protein from ...

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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
Journal:
Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
16
Issue:
9
Pages:
3045-3055
Publication date:
1996-05-01
EISSN:
1529-2401
ISSN:
0270-6474
Source identifiers:
397141
Language:
English
Keywords:
Pubs id:
pubs:397141
UUID:
uuid:7a9e0bf1-4ab8-4978-933f-b4a198d91aad
Local pid:
pubs:397141
Deposit date:
2013-11-16

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