Cost-effectiveness analyses alongside randomised clinical trials.
BACKGROUND: Many health economists increasingly advocate the use of model-based evaluations rather than trial-based evaluations. PURPOSE: The purpose of this paper is to review the merits and limitations of RCT-based evaluations of cost-effectiveness. RESULTS: The paper draws on the examples of large studies such as the United Kingdom Prospective Diabetes Study and the Heart Protection Study to suggest that large randomised trials offer a number of advantages to health economists wishing to ...Expand abstract
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