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Computational analysis of binding between malarial dihydrofolate reductases and anti-folates

Abstract:

Background: Plasmodium falciparum readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competitive drug binding at the enzyme's active site. Analogous mutations can be found in the DHFR gene in isolates of Plasmodium vivax (PvDHFR) although anti-folates have not been widely used for the treatment of this infection. Here the interactions between DHFR...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1475-2875-9-65

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Institution:
Kasetsart University, Bangkok, Thailand
Department:
Department of Biochemistry,Faculty of Science
Role:
Author
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Institution:
Mahidol University, Bangkok, Thailand
Department:
Department of Clinical Tropical Medicine,Faculty of Tropical Medicine
Role:
Author
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Institution:
Kasetsart University, Bangkok, Thailand
Department:
Department of Biochemistry,Faculty of Science
Role:
Author
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Institution:
"Mahidol University, Bangkok, Thailand", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
Role:
Author
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Institution:
"Mahidol University, Bangkok, Thailand", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
Role:
Author
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Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Malaria Journal Journal website
Volume:
9
Pages:
Article: 65
Publication date:
2010-03-05
DOI:
ISSN:
1475-2875
URN:
uuid:7a6d8118-0f8d-4c46-bbcd-04acfa91c3fb
Local pid:
ora:3724

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