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Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior.

Abstract:

Perisomatic inhibition provided by a subgroup of GABAergic interneurons plays a critical role in timing the output of pyramidal cells. To test their contribution at the network and the behavioral level, we generated genetically modified mice in which the excitatory drive was selectively reduced either by the knockout of the GluR-D or by conditional ablation of the GluR-A subunit in parvalbumin-positive cells. Comparable cell type-specific reductions of AMPA-mediated currents were obtained. Ka...

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Publication status:
Published

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Authors


Zivkovic, AR More by this author
Cunningham, MO More by this author
Middleton, S More by this author
Lebeau, FE More by this author
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Journal:
Neuron
Volume:
53
Issue:
4
Pages:
591-604
Publication date:
2007-02-05
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
URN:
uuid:7a61fac9-475c-4b12-a2b1-8b1d1ce3c61d
Source identifiers:
23034
Local pid:
pubs:23034

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