Clinical prediction modelling to guide decision making for essential neonatal services in Kenyan hospitals

Thesis

Introduction

More than 98% of neonatal deaths occur in low and middle income countries(LMICs) and hospitals in these regions are expected to play a key role toward achievement of SDG 3.2 “reduce neonatal mortality to 12 per 1000 live births and below. One approach in efforts to achieve this is to use data for decision making to improve quality of hospital care for neonates.

Methods

Using the largest neonatal unit data set in Kenya (11,850 observations): (1) I conducted the first analyses of in-hospital mortality in Kenya using Kaplan-Meier and Competing Risks analysis, (2) developed, validated and explored the potential utility of two novel and simple prognostic models using the Prognosis Research Strategy (PROGRESS) recommendations. Model development was informed by a systematic review guided by the Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies (CHARMS) recommendations.

Results

A tenth of the neonates studied died (839/9115, 9.2% [95% C. I 8.7 to 9.8%]). The overall median length of stay was 2 days (range of 0-98 days, IQR 1-5days). Competing risk analysis showed different cumulative incidence of death for the 1.5 to 1.99kg and 2 to 2.49kg weight categories that are often grouped together (1.5 to 2.49). In addition, the competing risk method provides a more clinically meaningful estimate of in-hospital death compared to Kaplan-Meier. Two simple prognostic models that use treatments (NETS) and signs and symptoms (SENSS) as predictors provide accurate predictions of in-hospital death. Discrimination by c-statistic is 0.89 for each model with calibration slope 0.90 for SENSS and 0.76 for NETS.

Conclusion

Prognostic data on in-hospital mortality may inform decisions on treatment, demand and capacity planning as well as balancing of groups in clinical trials. Scale up of such data collection and analyses is required in LMICs to support efforts to improve neonatal survival.

Authors: Aluvaala, M

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford