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Adaptation delay causes a burst of mutations in bacteria responding to oxidative stress

Abstract:

Understanding the interplay between phenotypic and genetic adaptation is a focus of evolutionary biology. In bacteria, the oxidative stress response prevents mutagenesis by reactive oxygen species (ROS). We hypothesise that the stress response dynamics can therefore affect the timing of the mutation supply that fuels genetic adaptation to oxidative stress. We uncover that sudden hydrogen peroxide stress causes a burst of mutations. By developing single-molecule and single-cell microscopy meth...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.15252/embr.202255640

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
New College
Role:
Author
ORCID:
0000-0002-3579-0888
Publisher:
EMBO Press
Journal:
EMBO Reports More from this journal
Volume:
24
Issue:
1
Article number:
e55640
Publication date:
2022-11-17
Acceptance date:
2022-10-28
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
Pmid:
36397732
Language:
English
Keywords:
Pubs id:
1308685
Local pid:
pubs:1308685
Deposit date:
2022-12-16

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