Journal article icon

Journal article

Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity.

Abstract:

OBJECTIVE: The precise molecular mechanisms contributing to the development of insulin resistance, impaired glucose tolerance (IGT), and type 2 diabetes are largely unknown. Altered endogenous glucocorticoid metabolism, including 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which generates active cortisol from cortisone, and 5alpha-reductase (5alphaR), which inactivates cortisol, has been implicated. RESEARCH DESIGN AND METHODS: A total of 101 obese patients (mean age 48 +/- 7 y...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.2337/db08-0495

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Hughes, BA More by this author
Hughes, SV More by this author
Expand authors...
Journal:
Diabetes
Volume:
57
Issue:
10
Pages:
2652-2660
Publication date:
2008-10-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:7a3bb89c-7ddf-4547-9edf-8f0748a3bfb8
Source identifiers:
482088
Local pid:
pubs:482088

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP