Journal article icon

Journal article

Blocking Synthesis of the Variant Surface Glycoprotein Coat in Trypanosoma brucei Leads to an Increase in Macrophage Phagocytosis Due to Reduced Clearance of Surface Coat Antibodies

Abstract:

The extracellular bloodstream form parasite Trypanosoma brucei is supremely adapted to escape the host innate and adaptive immune system. Evasion is mediated through an antigenically variable Variant Surface Glycoprotein (VSG) coat, which is recycled at extraordinarily high rates. Blocking VSG synthesis triggers a precytokinesis arrest where stalled cells persist for days in vitro with superficially intact VSG coats, but are rapidly cleared within hours in mice. We therefore investigated the ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.ppat.1006023

Authors


Cheung, JLY More by this author
Ridewood, S More by this author
More by this author
Department:
Oxford, MSD, Pathology Dunn School
Expand authors...

Contributors

Role:
Editor
Publisher:
Public Library of Science Publisher's website
Journal:
PLOS Pathogens Journal website
Volume:
12
Issue:
11
Publication date:
2016-11-28
Acceptance date:
2016-10-25
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pubs id:
pubs:664171
URN:
uri:7a36fd14-9a4c-4f99-9661-760ac43d8cb5
UUID:
uuid:7a36fd14-9a4c-4f99-9661-760ac43d8cb5
Local pid:
pubs:664171

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP