Journal article
Blocking Synthesis of the Variant Surface Glycoprotein Coat in Trypanosoma brucei Leads to an Increase in Macrophage Phagocytosis Due to Reduced Clearance of Surface Coat Antibodies
- Abstract:
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The extracellular bloodstream form parasite Trypanosoma brucei is supremely adapted to escape the host innate and adaptive immune system. Evasion is mediated through an antigenically variable Variant Surface Glycoprotein (VSG) coat, which is recycled at extraordinarily high rates. Blocking VSG synthesis triggers a precytokinesis arrest where stalled cells persist for days in vitro with superficially intact VSG coats, but are rapidly cleared within hours in mice. We therefore investigated the ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.3MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.ppat.1006023
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Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PLOS Pathogens More from this journal
- Volume:
- 12
- Issue:
- 11
- Publication date:
- 2016-11-28
- Acceptance date:
- 2016-10-25
- DOI:
- EISSN:
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1553-7374
- ISSN:
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1553-7366
Item Description
- Keywords:
- Pubs id:
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pubs:664171
- UUID:
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uuid:7a36fd14-9a4c-4f99-9661-760ac43d8cb5
- Local pid:
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pubs:664171
- Source identifiers:
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664171
- Deposit date:
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2016-12-05
Terms of use
- Copyright holder:
- Cheung et al
- Copyright date:
- 2016
- Notes:
- © 2016 Cheung et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
- Licence:
- CC Attribution (CC BY)
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