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Blocking Synthesis of the Variant Surface Glycoprotein Coat in Trypanosoma brucei Leads to an Increase in Macrophage Phagocytosis Due to Reduced Clearance of Surface Coat Antibodies

Abstract:

The extracellular bloodstream form parasite Trypanosoma brucei is supremely adapted to escape the host innate and adaptive immune system. Evasion is mediated through an antigenically variable Variant Surface Glycoprotein (VSG) coat, which is recycled at extraordinarily high rates. Blocking VSG synthesis triggers a precytokinesis arrest where stalled cells persist for days in vitro with superficially intact VSG coats, but are rapidly cleared within hours in mice. We therefore investigated the ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1006023

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Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Role:
Editor
Publisher:
Public Library of Science Publisher's website
Journal:
PLOS Pathogens Journal website
Volume:
12
Issue:
11
Chapter number:
e1006023
Publication date:
2016-11-28
Acceptance date:
2016-10-25
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pubs id:
pubs:664171
URN:
uri:7a36fd14-9a4c-4f99-9661-760ac43d8cb5
UUID:
uuid:7a36fd14-9a4c-4f99-9661-760ac43d8cb5
Local pid:
pubs:664171
Paper number:
11

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